Professor Charles Xavier and his team of genetically gifted superheroes face a rising tide of anti-mutant sentiment led by Col. William Stryker. Storm, Wolverine and Jean Grey must join their usual nemeses—Magneto and Mystique—to unhinge Stryker’s scheme to exterminate all mutants.
Michael spends quality time with Buster. George Michael auditions for a school play to get closer to Maeby. Gob breaks up with his girlfriend and has nowhere to go.
Michael and George Michael leave for Phoenix but go back to ensure the family misses them. Lindsay wants to have an open marriage, which causes Tobias to try to join the Blue Man Group under the impression that they are a support group for depressed men. Lucille signs Buster up for the army after being goaded by a Michael Moore lookalike. Gob becomes president of the Bluth Company.
George Sr. fears he’s losing Lucille to Oscar. Gob motivates Buster for the Army while Lindsay spends more time with Maeby to get closer to Steve Holt and Tobias starts working out.
In an effort to get to the bottom of things, Michael tracks Nellie down and hires her as a consultant for the Bluth Co. Unfortunately, Michael discovers Nellie's hands-on approach is more than he bargained for.
Michael is presented with a new business opportunity that could change his life, but unfortunately, he needs his family to sign off.
Buster's brief appearance in a TV weather report puts the Bluths back in hot water, but Michael has a plan involving his son's definitely real company.
Michael puts George Michael in charge of the Bluth Bannana Stand, and his son subsequently burns down the stand. Elsewhere, Tobias auditions for a commercial, and Lindsay inadvertantly gets the part.
In the first season finale, George Sr. has a heart attack, and Maeby is jealous when George Michael likes another girl. Meanwhile, Lindsay decides to leave Tobias until a book he wrote a long time ago becomes a gay bestseller, and Buster and Annyong compete over women.
After Michael announces he’s marrying Rita, George Sr. worries that she’s after the family’s money. But when Rita’s Uncle Trevor tries to stop the wedding by revealing some surprising information about Rita, Michael must decide if he wants to walk down the aisle.