Professor Charles Xavier and his team of genetically gifted superheroes face a rising tide of anti-mutant sentiment led by Col. William Stryker. Storm, Wolverine and Jean Grey must join their usual nemeses—Magneto and Mystique—to unhinge Stryker’s scheme to exterminate all mutants.
Buster realizes that medical marijuana will help cure Lucille 2’s vertigo, and pays George Michael to get it for him from Gob. Lindsay sends Maeby to spend a day with Lucille to punish her for bad grades. Michael thinks George Michael is on drugs and attempts to teach him a lesson.
Michael tries to find out who’s the father of Maggie’s baby, or if it’s just another of her lies; Gob tries to find out whether he was responsible for Buster’s accident.
George Sr. tries to find a way to attend an anniversary dinner for Lucille while Michael deliberately offends Ann’s devout Christian parents. Tobias goes overboard performing his “Mrs. Featherbottom” persona.
Gob accepts a job from his brother, but is distracted by a scheme of his own.
For varying reasons, most of the Bluths (even Steve Holt) feel compelled to run off to Mexico. Michael tries to convince Buster to go to the police.
Michael cannot go through with his plan to break up Gob and Marta. A thug magician wants to take Gob’s “legs”. Maeby wears all leather to get back at her mother, and Lucille decides to confront Buster’s relationship with Lucille 2.
Just as Michael’s relationship with Sally starts to flourish, Maggie Lizer returns nine months pregnant, and Michael immediately assumes he’s the father. George Michael attempts to break up with Ann, and Buster learns he’s being deployed to Iraq.
Gob and Buster team up for some magic tricks with the help of Buster's fake hand, but when Tony Wonder, a rival magician, starts to mentor them, somebody gets the finger. Meanwhile, Michael is forced to delegate some work when he's hospitalized and Lindsay teaches George Michael how to drive using the staircar.
Lucille finds that her children have started dividing up her things, and adjusts to her new home.
